Description

4-Aminomethyl-2,3-Dihydro-Indole-1-Carboxylic Acid tert-Butyl Ester is a high-purity, protected indole derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in its functionalized indole scaffold and protected amine group, enabling efficient construction of complex molecular architectures. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of central nervous system (CNS) active compounds, serotonin receptor modulators, and other bioactive molecules.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides that require specific indole-based frameworks.
• Peptidomimetics & Drug Discovery: Employed as a constrained amino acid surrogate in the design of peptide analogs and small-molecule drug candidates to improve metabolic stability and binding affinity.
• Asymmetric Catalysis Substrate: Serves as a substrate in catalytic asymmetric transformations to introduce chirality into complex molecules.
• Chemical Biology Probe Development: Utilized in the synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and contract research organizations (CROs) specializing in heterocyclic chemistry.

Basic Information

Product Name	4-Aminomethyl-2,3-Dihydro-Indole-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1086392-32-6
Molecular Formula	C15H20N2O2
Molecular Weight	260.33 g/mol
Synonyms	1-Boc-4-(aminomethyl)indoline; tert-Butyl 4-(aminomethyl)-2,3-dihydro-1H-indole-1-carboxylate; 4-(Aminomethyl)indoline-1-carboxylic acid tert-butyl ester; 1H-Indole-1-carboxylic acid, 4-(aminomethyl)-2,3-dihydro-, 1,1-dimethylethyl ester; 4-Aminomethylindoline-1-carboxylic acid tert-butyl ester; Boc-4-aminomethylindoline; 1-N-Boc-4-aminomethylindoline
EINECS	Contact for details

Quality Control

Our 4-Aminomethyl-2,3-Dihydro-Indole-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided for every shipment, supporting compliance in cGMP and ISO 9001 environments for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.