Description

tert-Butyl 3-(Aminomethyl)Indoline-1-Carboxylate is a high-purity, protected indoline derivative featuring both a Boc-protected amine and a primary aminomethyl group, making it a versatile and valuable synthetic intermediate. This compound is specifically engineered for advanced pharmaceutical research and development, offering a critical building block for constructing complex molecular architectures. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce the indoline scaffold with orthogonal amine protection.
• Process Chemistry Development: Serves as a standardized starting material for scaling up synthetic routes under current Good Manufacturing Practice (cGMP) conditions.
• Peptidomimetic Synthesis: The indoline core and functional groups are valuable for creating constrained peptide analogs and protease inhibitors.
• Ligand and Catalyst Development: Employed in the preparation of novel chiral ligands for asymmetric catalysis or as a precursor for metal-organic frameworks (MOFs).
• Chemical Biology Probes: Useful for synthesizing tagged molecules for studying biological pathways and target engagement.

Basic Information

Product Name	tert-Butyl 3-(Aminomethyl)Indoline-1-Carboxylate
CAS No.	1086392-24-6
Molecular Formula	C15H22N2O2
Molecular Weight	262.35 g/mol
Synonyms	1-Boc-3-(aminomethyl)indoline; tert-Butyl 3-(aminomethyl)-2,3-dihydro-1H-indole-1-carboxylate; 3-(Aminomethyl)indoline-1-carboxylic acid tert-butyl ester; 1H-Indole-1-carboxylic acid, 3-(aminomethyl)-2,3-dihydro-, 1,1-dimethylethyl ester; 1,1-Dimethylethyl 3-(aminomethyl)-2,3-dihydro-1H-indole-1-carboxylate; 3-Aminomethylindoline-1-carboxylic acid tert-butyl ester; Boc-3-(aminomethyl)indoline; N-Boc-3-(aminomethyl)indoline
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(Aminomethyl)Indoline-1-Carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A detailed Certificate of Analysis (COA) is supplied with each batch, documenting compliance with customer specifications and internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Keep the container tightly sealed in a desiccated environment after opening.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.