Description

7-Trifluoromethoxy-1H-Indazole-3-Carboxylic Acid Methyl Ester CAS NO 1086392-22-4 is a high-purity, advanced pharmaceutical intermediate featuring a unique indazole core functionalized with a trifluoromethoxy group. This compound is a critical building block in modern medicinal chemistry, prized for its ability to impart favorable metabolic stability and lipophilicity to target molecules. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs) targeting protein kinases and other enzymes.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Agrochemical Development: Used in the research and synthesis of novel herbicides and fungicides, leveraging the bioactivity of the indazole moiety.
• Material Science Precursor: Potential intermediate for the synthesis of specialty polymers and liquid crystals due to its aromatic and fluorinated structure.

Basic Information

Product Name	7-Trifluoromethoxy-1H-Indazole-3-Carboxylic Acid Methyl Ester
CAS No.	1086392-22-4
Molecular Formula	C10H7F3N2O3
Molecular Weight	260.17 g/mol
Synonyms	Methyl 7-(trifluoromethoxy)-1H-indazole-3-carboxylate; 1H-Indazole-3-carboxylic acid, 7-(trifluoromethoxy)-, methyl ester; 7-Trifluoromethoxyindazole-3-carboxylic acid methyl ester; 7-(Trifluoromethoxy)-1H-indazole-3-carboxylic acid methyl ester; CAS 1086392-22-4
EINECS	Contact for details

Quality Control

Our production of 7-Trifluoromethoxy-1H-Indazole-3-Carboxylic Acid Methyl Ester adheres to stringent quality management protocols. Each batch is characterized and tested to ensure identity, purity, and consistency, meeting the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥97% by HPLC), residual solvents, and other critical parameters is provided with every shipment to guarantee supply reliability and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from direct light to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.