Description

3-Iodo 1H-Indazole-6-Carboxylic Acid is a high-purity, functionalized heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a key intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

This versatile iodinated indazole derivative serves as a critical synthon in various high-value chemical syntheses. Its primary applications include:

• Pharmaceutical Intermediate: A key building block for the synthesis of potential drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and plant growth regulators.
• Material Science: Serves as a precursor for organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Chemical Biology: Employed in the synthesis of molecular probes and tags for studying biological processes.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings.
• Library Synthesis: Used in parallel and combinatorial chemistry to generate diverse compound libraries for high-throughput screening.

Basic Information

Product Name	3-Iodo 1H-Indazole-6-Carboxylic Acid
CAS No.	1086391-11-8
Molecular Formula	C8H5IN2O2
Molecular Weight	288.04 g/mol
Synonyms	3-Iodo-1H-indazole-6-carboxylic acid; 6-Carboxy-3-iodo-1H-indazole; 1H-Indazole-6-carboxylic acid, 3-iodo-; 3-Iodoindazole-6-carboxylic acid; 1086391-11-8; AI3-32817; AKOS040759625; BDBM50382889; CTK8G7151; MolPort-002-783-947; ZINC000257630911
EINECS	Contact for details

Quality Control

Our 3-Iodo 1H-Indazole-6-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.