Description

5-Bromo-2-Ethoxy-Thiazole is a high-purity brominated thiazole derivative, a crucial heterocyclic building block in advanced organic synthesis. Its value lies in its role as a versatile intermediate for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce functionalized thiazole motifs into their target molecules.

Application

• Pharmaceutical Intermediate: Key synthon for the research and development of novel drug candidates, particularly in kinase inhibitors, antiviral agents, and anti-inflammatory compounds.
• Agrochemical Synthesis: Used in the production of advanced fungicides, herbicides, and insecticides where the thiazole core provides essential bioactivity.
• Material Science Research: Serves as a precursor for functional organic materials, including liquid crystals, organic semiconductors, and photoactive compounds.
• Chemical Biology & Proteomics: Employed as a building block for activity-based probes and molecular tags to study biological systems.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Negishi couplings for carbon-carbon bond formation.
• Heterocyclic Chemistry Library Development: A valuable starting material for generating diverse compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	5-Bromo-2-Ethoxy-Thiazole
CAS No.	1086382-60-6
Molecular Formula	C5H6BrNOS
Molecular Weight	208.08 g/mol
Synonyms	2-Ethoxy-5-bromothiazole; 5-Bromo-2-ethoxythiazole; Thiazole, 5-bromo-2-ethoxy-; 1086382-60-6; 5-Bromo-2-ethoxy-1,3-thiazole; 2-Ethoxy-5-bromo-1,3-thiazole
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-2-Ethoxy-Thiazole is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.