Description

2-Bromo-5-Cyclopropylthiazole is a high-value, heterocyclic building block featuring a reactive bromine atom and a cyclopropyl substituent on a thiazole core. This compound matters as a versatile intermediate for constructing complex molecular architectures in advanced pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for applications such as Suzuki-Miyaura cross-coupling and as a precursor to novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents, including fungicides and herbicides, leveraging the biological activity of the thiazole moiety.
• Cross-Coupling Reactions: Serves as an excellent electrophilic partner in palladium-catalyzed cross-coupling reactions, such as Suzuki, Stille, and Sonogashira couplings, to introduce the 5-cyclopropylthiazole fragment.
• Material Science Research: Investigated as a precursor for organic electronic materials and liquid crystals due to the unique electronic properties of the thiazole ring.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specialized heterocyclic blocks.

Basic Information

Product Name	2-Bromo-5-Cyclopropylthiazole
CAS No.	1086381-69-2
Molecular Formula	C6H6BrNS
Molecular Weight	204.09 g/mol
Synonyms	2-Bromo-5-cyclopropyl-1,3-thiazole; 5-Cyclopropyl-2-bromothiazole; Thiazole, 2-bromo-5-cyclopropyl-; 1086381-69-2; 2-Bromo-5-cyclopropylthiazole; Bromocyclopropylthiazole
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-5-Cyclopropylthiazole is produced under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency suitable for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee reliable and reproducible performance in your synthetic workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is light-sensitive (store away from light) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.