Description

2-Amino-5-(Trifluoromethyl)Thiazole-4-Carboxylic Acid is a high-value trifluoromethylated thiazole derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, combining a carboxylic acid group with an amino-substituted thiazole ring and a trifluoromethyl moiety, makes it indispensable for creating novel compounds with enhanced biological activity and physicochemical properties. This intermediate is primarily sought by pharmaceutical and agrochemical R&D teams for the development of new active ingredients, including potential drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel drug candidates, particularly in medicinal chemistry programs targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced pesticides, herbicides, and fungicides, where the trifluoromethyl group can improve metabolic stability and bioavailability.
• Chemical Research & Development: Serves as a versatile scaffold in academic and industrial labs for exploring new chemical spaces and synthesizing complex heterocyclic compounds.
• Material Science Precursor: Potential use in the synthesis of specialty chemicals and functional materials, such as ligands for catalysis or components for electronic materials.

Basic Information

Product Name	2-Amino-5-(Trifluoromethyl)Thiazole-4-Carboxylic Acid
CAS No.	1086380-23-5
Molecular Formula	C5H3F3N2O2S
Molecular Weight	212.15 g/mol
Synonyms	2-Amino-5-(trifluoromethyl)-1,3-thiazole-4-carboxylic acid; 4-Thiazolecarboxylic acid, 2-amino-5-(trifluoromethyl)-; 5-(Trifluoromethyl)-2-aminothiazole-4-carboxylic acid; ATFTC; 2-Amino-α,α,α-trifluoro-4-thiazoleacetic acid (tautomeric form); 2-Amino-5-trifluoromethylthiazole-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 2-Amino-5-(Trifluoromethyl)Thiazole-4-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to verify identity and quantify purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support development and commercial projects requiring material that meets internal specifications or aligns with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.