Description

5-(1H-Imidazol-4-Yl)Thiophene-2-Carboxylic Acid is a high-value heterocyclic building block featuring a fused imidazole-thiophene core. This compound is essential for medicinal chemistry research and pharmaceutical development, serving as a key precursor for synthesizing novel small molecule therapeutics. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors. The CAS number for this compound is 1086380-04-2.

Application

This versatile heterocyclic intermediate is designed for advanced synthetic applications, particularly in the development of active pharmaceutical ingredients (APIs).

• Pharmaceutical Intermediate: A critical building block for the synthesis of kinase inhibitors and other targeted small molecule drugs.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore novel chemical space and structure-activity relationships (SAR).
• Agrochemical Development: Serves as a precursor in the creation of new fungicides or herbicides with specific modes of action.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and cellular pathways.
• Material Science: Potential precursor for organic electronic materials or metal-organic frameworks (MOFs) due to its conjugated system and coordination sites.

Basic Information

Product Name	5-(1H-Imidazol-4-Yl)Thiophene-2-Carboxylic Acid
CAS No.	1086380-04-2
Molecular Formula	C8H6N2O2S
Molecular Weight	194.21 g/mol
Synonyms	4-(2-Carboxythiophen-5-yl)-1H-imidazole; 5-(1H-Imidazol-4-yl)-2-thiophenecarboxylic acid; 5-(1H-Imidazol-4-yl)thiophene-2-carboxylic acid; 2-Thiophenecarboxylic acid, 5-(1H-imidazol-4-yl)-; 1086380-04-2; 5-(1H-Imidazol-4-yl)thiophene-2-carboxylate
EINECS	Contact for details

Quality Control

Our 5-(1H-Imidazol-4-Yl)Thiophene-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.