Description

1H-Indazole, 3-Bromo-5-(Trifluoromethyl)- is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound is valued for its unique molecular architecture, which combines a bromo-substituted indazole core with a trifluoromethyl group, enabling precise molecular modifications. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in kinase inhibitor and oncology research programs.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging the biological activity of the indazole scaffold.
• Material Science Research: Serves as a precursor for creating specialized organic ligands, dyes, and functional polymers.
• Chemical Biology Probes: Employed in the design of molecular probes and tags for studying biological pathways and mechanisms.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings.
• Fluorine Chemistry: The trifluoromethyl group provides a metabolically stable and lipophilic moiety, crucial for optimizing the pharmacokinetic properties of lead compounds.

Basic Information

Product Name	1H-Indazole, 3-Bromo-5-(Trifluoromethyl)-
CAS No.	1086378-32-6
Molecular Formula	C8H4BrF3N2
Molecular Weight	265.03 g/mol
Synonyms	3-Bromo-5-(trifluoromethyl)-1H-indazole; 3-Bromo-5-(trifluoromethyl)indazole; 5-(Trifluoromethyl)-3-bromo-1H-indazole; 1H-Indazole, 3-bromo-5-(trifluoromethyl)-; 1086378-32-6; 3-Bromo-5-trifluoromethylindazole; 3-Br-5-CF3-1H-indazole
EINECS	Contact for details

Quality Control

Every batch of 1H-Indazole, 3-Bromo-5-(Trifluoromethyl)- is manufactured and tested under a strict quality management system to ensure consistency and reliability for your critical research and development. We provide comprehensive Certificates of Analysis (COA) that detail purity, identity, and impurity profiles. Our standard grade meets high-purity research specifications, and we can support development with custom purity grades upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.