Description

5-Oxo-L-Proline-D5 is a stable isotope-labeled analog of 5-oxoproline, where five hydrogen atoms are replaced with deuterium. This high-purity compound is essential for advanced analytical and research applications requiring precise internal standards. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and metabolomics sectors for quantitative mass spectrometry and metabolic pathway studies.

Application

• Internal Standard for LC-MS/MS and GC-MS analysis in bioanalytical studies.
• Metabolomics research for investigating the glutathione biosynthesis and γ-glutamyl cycles.
• Pharmaceutical development and drug metabolism/pharmacokinetics (DMPK) studies.
• Stable Isotope Labeling by Amino acids in Cell culture (SILAC) applications in proteomics.
• Quality control and method validation in analytical chemistry laboratories.
• Biochemical research into oxidative stress and related metabolic disorders.

Basic Information

Product Name	5-Oxo-L-Proline-D5
CAS No.	1086136-22-2
Molecular Formula	C₅H₂D₅NO₃
Molecular Weight	147.13 g/mol (for deuterated form)
Synonyms	L-Pyroglutamic Acid-d5; (S)-5-Oxopyrrolidine-2-carboxylic Acid-d5; PCA-d5; Pyroglutamic Acid-d5; 5-Oxo-D-proline-d5; Glutamic Acid Lactam-d5; 2-Pyrrolidone-5-carboxylic Acid-d5
EINECS	Contact for details

Quality Control

Our 5-Oxo-L-Proline-D5 is manufactured under strict quality systems to ensure high isotopic purity and chemical integrity. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (D-content), chemical purity, and specific optical rotation. We adhere to relevant standards for research chemicals, ensuring reliability for your critical analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Specific Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.