Description

10-Chloro-2,3,4,6,7,11B-Hexahydro-1H-Pyrazino[2,1-A]Isoquinoline is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and other therapeutic areas. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of new drug candidates, especially those targeting neurological pathways.
• Organic Synthesis Building Block: Used in medicinal chemistry for constructing complex polycyclic frameworks and exploring structure-activity relationships (SAR).
• Research & Development (R&D): Serves as a standard or starting material in academic and industrial research for pharmacological studies.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial manufacturing of target APIs.
• Reference Standard: Can be utilized as an analytical standard for quality control and method validation in API production.

Basic Information

Product Name	10-Chloro-2,3,4,6,7,11B-Hexahydro-1H-Pyrazino[2,1-A]Isoquinoline
CAS No.	1082914-74-6
Molecular Formula	C12H15ClN2
Molecular Weight	222.71 g/mol
Synonyms	10-Chloro-1,2,3,4,6,7-hexahydro-11bH-pyrazino[2,1-a]isoquinoline; 10-Chloro-2,3,4,6,7,11b-hexahydro-1H-pyrazino[2,1-a]isoquinoline; Pyrazino[2,1-a]isoquinoline, 10-chloro-1,2,3,4,6,7-hexahydro-; 1082914-74-6; UNII-8K4V5N2I1F; 8K4V5N2I1F
EINECS	Contact for details

Quality Control

Our 10-Chloro-2,3,4,6,7,11B-Hexahydro-1H-Pyrazino[2,1-A]Isoquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided and can be tailored to meet specific client requirements for research or cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.