Description

10-Chloro-2,3,6,7-Tetrahydro-1H-Pyrazino[2,1-A]Isoquinolin-4(11Bh)-One is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel drug candidates targeting neurological disorders.
• Organic Synthesis Building Block: Used in complex multi-step organic syntheses to construct fused polycyclic systems for medicinal chemistry research.
• Research & Development (R&D): Serves as a standard or starting material in academic and industrial R&D labs for pharmacological studies and structure-activity relationship (SAR) optimization.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in the scaled-up production of specific APIs under current Good Manufacturing Practice (cGMP) conditions.
• Contract Manufacturing: Supplied to CDMOs for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Item	Details
Product Name	10-Chloro-2,3,6,7-Tetrahydro-1H-Pyrazino[2,1-A]Isoquinolin-4(11Bh)-One
CAS No.	1082914-63-3
Molecular Formula	C₁₄H₁₃ClN₂O
Molecular Weight	260.72 g/mol
Synonyms	10-Chloro-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one; 10-Chloro-2,3,6,7-tetrahydro-1H,4H,11bH-pyrazino[2,1-a]isoquinolin-4-one; 10-Chloro-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one; 1082914-63-3; UNII-9J2F7P869N; 9J2F7P869N; Pyrazino[2,1-a]isoquinolin-4-one, 10-chloro-1,2,3,6,7,11b-hexahydro-
EINECS	Contact for details

Quality Control

Every batch of 10-Chloro-2,3,6,7-Tetrahydro-1H-Pyrazino[2,1-A]Isoquinolin-4(11Bh)-One is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) including purity (HPLC), identity (IR, NMR), and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.