Description

6-Fluoro-1H-Indole-4-Carboxylic Acid Methyl Ester is a high-value fluorinated indole derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in providing a versatile scaffold for constructing complex molecules, particularly in the development of novel active pharmaceutical ingredients (APIs). This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to introduce fluorine atoms and indole motifs into their target structures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory applications.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and plant growth regulators where the indole core and fluorine substitution can enhance biological activity and environmental stability.
• Material Science: Serves as a monomer or functionalizing agent in the creation of specialty polymers, organic semiconductors, and liquid crystals with tailored electronic properties.
• Chemical Biology & Proteomics: Employed as a fluorescent probe precursor or a tag for labeling biomolecules due to the photophysical properties of the indole fluorophore.
• Academic & Contract Research: A valuable reagent for methodological studies in organic chemistry, including cross-coupling reactions, heterocyclic chemistry, and fluorine chemistry.

Basic Information

Product Name	6-Fluoro-1H-Indole-4-Carboxylic Acid Methyl Ester
CAS No.	1082040-43-4
Molecular Formula	C10H8FNO2
Molecular Weight	193.17 g/mol
Synonyms	Methyl 6-Fluoro-1H-indole-4-carboxylate; 6-Fluoro-1H-indole-4-carboxylic acid methyl ester; 4-Carbomethoxy-6-fluoroindole; 6-Fluoroindole-4-carboxylic Acid Methyl Ester; 1H-Indole-4-carboxylic acid, 6-fluoro-, methyl ester; Methyl 6-fluoro-4-indolecarboxylate; 6-Fluoro-4-(methoxycarbonyl)-1H-indole
EINECS	Contact for details

Quality Control

Our 6-Fluoro-1H-Indole-4-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.