Description

3-Iodo-4-Chloro-5-Bromo-(1H)Indazole is a highly functionalized, multi-halogenated indazole derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its unique halogen substitution pattern makes it a valuable scaffold for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for drug discovery and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and oncology research programs.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides due to its halogen-rich structure.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the creation of specialty polymers and organic electronic materials.
• Chemical Biology Probe: Employed in the design of molecular probes and activity-based protein profiling (ABPP) reagents.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to introduce the indazole core into more complex architectures.
• Library Synthesis: A versatile starting material for generating diverse compound libraries in high-throughput screening for biological activity.

Basic Information

Product Name	3-Iodo-4-Chloro-5-Bromo-(1H)Indazole
CAS No.	1082040-21-8
Molecular Formula	C7H3BrClIN2
Molecular Weight	356.37 g/mol
Synonyms	3-Iodo-4-chloro-5-bromo-1H-indazole; 4-Chloro-5-bromo-3-iodo-1H-indazole; 1H-Indazole, 3-iodo-4-chloro-5-bromo-; 5-Bromo-4-chloro-3-iodo-1H-indazole; 1082040-21-8; 3-Iodo-4-chloro-5-bromoindazole; 4-Chloro-5-bromo-3-iodoindazole
EINECS	Contact for details

Quality Control

Our 3-Iodo-4-Chloro-5-Bromo-(1H)Indazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under inert atmosphere when appropriate for prolonged use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.