Description

3-Hydroxy Agomelatine D3 is a key pharmaceutical intermediate and analytical reference standard, specifically the 3-hydroxy metabolite of Agomelatine. This compound is critical for research and development in neuropsychiatric pharmacology, enabling the study of drug metabolism and pharmacokinetics. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories focused on developing and validating therapies for depression and circadian rhythm disorders.

Application

• Pharmaceutical Intermediate: Synthesis of advanced metabolites and related analogs for neuropsychiatric drug discovery.
• Metabolite Reference Standard: Essential for bioanalytical method development and validation in pharmacokinetic (PK) and toxicokinetic (TK) studies.
• Drug Impurity Profiling: Used as a certified reference material to identify, quantify, and control the 3-hydroxy metabolite impurity in Agomelatine Active Pharmaceutical Ingredient (API).
• Clinical Research: Supports studies investigating the metabolic pathways and efficacy of Agomelatine and its derivatives.
• Quality Control (QC) Testing: Serves as a high-purity standard in HPLC and LC-MS/MS assays for pharmaceutical quality assurance laboratories.

Basic Information

Product Name	3-Hydroxy Agomelatine D3
CAS No.	1079774-23-4
Molecular Formula	C₁₇H₁₇D₃NO₃
Molecular Weight	287.36 g/mol
Synonyms	N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide-3-hydroxy-d3; 3-Hydroxy Agomelatine-d3; Deuterated 3-Hydroxy Agomelatine; Agomelatine 3-hydroxy Metabolite D3; S 20098-3-OH D3; S20098 Metabolite D3; 3-OH Agomelatine D3
EINECS	Contact for details

Quality Control

Our 3-Hydroxy Agomelatine D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research and pharmaceutical reference standard requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.