Description

Agomelatine-D3 (Acetamide-2,2,2-D3) is a deuterium-labeled analog of the active pharmaceutical ingredient Agomelatine, specifically designed for use as an internal standard in quantitative analytical methods. This stable isotope-labeled compound is essential for ensuring the accuracy and reliability of mass spectrometry-based analyses, such as LC-MS/MS, by correcting for variations in sample preparation and instrument performance. It is a critical tool for pharmaceutical researchers, analytical laboratories, and quality control departments engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and impurity profiling.

Application

• Internal Standard for LC-MS/MS Analysis: Primary use as a quantitative reference standard in bioanalytical assays for Agomelatine.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in tracing and quantifying the parent drug and its metabolites in biological matrices (plasma, serum, urine).
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradation products.
• Clinical Research: Supports accurate therapeutic drug monitoring and bioavailability/bioequivalence studies.
• Forensic Toxicology: Employed in confirmatory testing for the presence of Agomelatine in forensic samples.
• Method Development and Validation: Critical for developing robust, sensitive, and specific analytical methods compliant with ICH guidelines.

Basic Information

Item	Detail
Product Name	Agomelatine-D3 (Acetamide-2,2,2-D3)
CAS No.	1079389-38-0
Molecular Formula	C₁₅H₁₄D₃NO₂
Molecular Weight	~246.33 g/mol
Synonyms	N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide-2,2,2-d3; Agomelatine-d3; S 20098-d3; Deuterated Agomelatine; Agomelatine Internal Standard; Agomelatine-d3 (acetamide-d3); N-(2-(7-Methoxynaphthalen-1-yl)ethyl)acetamide-2,2,2-d3
EINECS	Contact for details

Quality Control

Every batch of Agomelatine-D3 (Acetamide-2,2,2-D3) is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, with comprehensive testing including HPLC for chemical purity, NMR and MS for structural and isotopic confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (by NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.