Description

Diethyl (6-Chloro-2-Indolylmethyl)Formamido-Malonate is a high-purity, advanced pharmaceutical intermediate characterized by its specific indole-based molecular architecture. This compound matters for its critical role as a key building block in the synthesis of complex bioactive molecules, particularly in medicinal chemistry research and development. Pharmaceutical companies, contract research organizations (CROs), and fine chemical manufacturers need it for developing new drug candidates, especially those targeting neurological and oncological pathways.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of novel active pharmaceutical ingredients (APIs), particularly for investigational drugs.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Process Chemistry Development: Used in route scouting and optimization for the scalable production of complex heterocyclic target molecules.
• Academic & Institutional R&D: Employed in university and research institute laboratories for synthesizing specialized compounds for biological evaluation.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP guidelines.

Basic Information

Product Name	Diethyl (6-Chloro-2-Indolylmethyl)Formamido-Malonate
CAS No.	1076199-98-8
Molecular Formula	C₁₇H₁₉ClN₂O₅
Molecular Weight	366.80 g/mol
Synonyms	Diethyl 2-[[(6-Chloro-1H-indol-2-yl)methyl]formamido]malonate; 2-[[(6-Chloro-1H-indol-2-yl)methyl]formamido]malonic Acid Diethyl Ester; Diethyl (6-Chloro-2-indolylmethyl)formamidomalonate; (6-Chloro-1H-indol-2-yl)methyl]formamido-malonic Acid Diethyl Ester; 6-Chloro-2-indolylmethyl Formamido Malonate Diethyl Ester; Diethyl (6-Chloro-2-Indolylmethyl)Formamido-Malonate; CAS 1076199-98-8
EINECS	Contact for details

Quality Control

Our Diethyl (6-Chloro-2-Indolylmethyl)Formamido-Malonate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements, including custom purity grades.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere when appropriate to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.