Description

3-(Maleimidopropane-1-Carbonyl-1-(tert-Butyl)Carbazate is a high-purity, heterobifunctional crosslinking reagent featuring a maleimide group and a protected carbazate functionality. This compound is critical for creating stable, site-specific conjugations between amine-containing molecules and thiol-containing biomolecules under mild conditions. It is primarily utilized by researchers and manufacturers in the pharmaceutical and bioconjugation sectors for developing antibody-drug conjugates (ADCs), protein labeling, and advanced polymer synthesis.

Application

• Antibody-Drug Conjugate (ADC) Linker Synthesis: Serves as a key intermediate for constructing cleavable or non-cleavable linkers, enabling the precise attachment of cytotoxic payloads to monoclonal antibodies.
• Protein and Peptide Modification: Enables site-specific labeling and functionalization of proteins, peptides, and other biomolecules via thiol-maleimide chemistry for diagnostic and therapeutic applications.
• Polymer and Material Science: Used in the synthesis of functionalized polymers, hydrogels, and smart materials where controlled crosslinking and bioconjugation are required.
• Bioconjugation Reagent Kits: A vital component in commercial and research-grade kits designed for labeling, immobilization, and detection assays.
• Surface Immobilization: Facilitates the covalent attachment of biomolecules to sensor chips, nanoparticles, and other solid supports for biosensing and diagnostic platforms.
• Protecting Group Strategy in Organic Synthesis: The tert-butyl carbazate (Boc-hydrazide) group acts as a protective moiety for carbonyls, useful in multi-step synthetic routes for complex molecules.

Basic Information

Product Name	3-(Maleimidopropane-1-Carbonyl-1-(tert-Butyl)Carbazate
CAS No.	1076198-38-3
Molecular Formula	C13H19N3O5
Molecular Weight	297.31 g/mol
Synonyms	1-Boc-2-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl]hydrazine; tert-Butyl 2-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl]hydrazine-1-carboxylate; 3-(Maleimidopropane-1-Carbonyl-1-Boc-Carbazate; Maleimide-PEG3-Boc-hydrazide; 1-Boc-2-(3-maleimidopropanoyl)hydrazine; Boc-Hydrazide-PEG3-Maleimide; N-(t-Butoxycarbonyl)-N'-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl]hydrazine
EINECS	Contact for details

Quality Control

Our 3-(Maleimidopropane-1-Carbonyl-1-(tert-Butyl)Carbazate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to support research and cGMP-grade applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. For long-term storage under an inert atmosphere, it is recommended to keep the product desiccated at -20°C. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.