Description

(1R,2R)-1-[(3,4-Dimethoxyphenyl)Methyl]-2-[3-(tert-Butoxy)-3-Oxopropyl]-1,2,3,4-Tetrahydro-6,7-Dimethoxy-2-Methylisoquinolinium Benzenesulfonate is a high-purity, non-racemic chiral salt of significant interest in advanced pharmaceutical research and development. This compound serves as a critical advanced pharmaceutical intermediate (API intermediate) or a reference standard for the synthesis of complex bioactive molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors working on novel therapeutics, particularly in areas requiring stereochemical control.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex, chiral active pharmaceutical ingredients (APIs) targeting neurological and cardiovascular diseases.
• Chemical Reference Standard: Used for analytical method development, validation, and quality control in pharmaceutical manufacturing to ensure product identity and purity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization for new drug candidates.
• Process Chemistry Development: Serves as a model compound for developing and scaling up asymmetric synthesis routes.
• Academic & Institutional Research: Used in university and research institute laboratories for studies in organic synthesis and pharmacology.

Basic Information

Product Name	(1R,2R)-1-[(3,4-Dimethoxyphenyl)Methyl]-2-[3-(tert-Butoxy)-3-Oxopropyl]-1,2,3,4-Tetrahydro-6,7-Dimethoxy-2-Methylisoquinolinium Benzenesulfonate
CAS No.	1075727-00-2
Molecular Formula	C34H45NO9S
Molecular Weight	643.79 g/mol
Synonyms	(1R,2R)-1-[(3,4-Dimethoxyphenyl)methyl]-2-[3-(tert-butoxy)-3-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolinium benzenesulfonate; (1R,2R)-1-[(3,4-Dimethoxyphenyl)methyl]-2-[3-(tert-butoxy)-3-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolin-1-ium benzenesulfonate; Benzenesulfonic acid, compd. with (1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-2-[3-(1,1-dimethylethoxy)-3-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinoline (1:1); (1R,2R)-THIQ Benzenesulfonate Derivative; (1R,2R)-Tetrahydroisoquinolinium Salt
EINECS	Contact for details

Quality Control

Our (1R,2R)-1-[(3,4-Dimethoxyphenyl)Methyl]-2-[3-(tert-Butoxy)-3-Oxopropyl]-1,2,3,4-Tetrahydro-6,7-Dimethoxy-2-Methylisoquinolinium Benzenesulfonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral assay, NMR and IR for structural confirmation, and residual solvent analysis to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) documenting identity, purity, and specific impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. The compound may be hygroscopic; keep the container tightly sealed in a dry environment. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.