Description

(8β)-8-(Hydroxymethyl)Ergoline-1,6-Dicarboxylic Acid 1,6-Bis(1,1-Dimethylethyl) Ester is a high-purity, advanced pharmaceutical intermediate of significant interest in modern synthetic chemistry. This compound is valued for its role as a key synthetic precursor in the development of complex ergoline-based active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis and process development of novel therapeutic agents targeting neurological and cardiovascular systems.

Application

• Pharmaceutical Intermediate: Critical building block in the multi-step synthesis of complex ergoline alkaloid derivatives and APIs.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new drug candidates.
• Process Chemistry: Serves as a key starting material or intermediate in the scale-up and optimization of synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Item	Details
Product Name	(8β)-8-(Hydroxymethyl)Ergoline-1,6-Dicarboxylic Acid 1,6-Bis(1,1-Dimethylethyl) Ester
CAS No.	1075250-75-7
Molecular Formula	C28H38N2O5
Molecular Weight	482.61 g/mol
Synonyms	8-(Hydroxymethyl)ergoline-1,6-dicarboxylic acid 1,6-di-tert-butyl ester; 1,6-Di-tert-butyl 8-(hydroxymethyl)ergoline-1,6-dicarboxylate; (8β)-8-(Hydroxymethyl)-1,6-bis(1,1-dimethylethyl) 1,2,6,7,8,8a-hexahydro-3H-pyrrolo[2,3-g]isoquinoline-1,6-dicarboxylate; Ergoline-1,6-dicarboxylic acid, 8-(hydroxymethyl)-, 1,6-bis(1,1-dimethylethyl) ester, (8β)-; CAS 1075250-75-7
EINECS	Contact for details

Quality Control

Our (8β)-8-(Hydroxymethyl)Ergoline-1,6-Dicarboxylic Acid 1,6-Bis(1,1-Dimethylethyl) Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.