Description

(8β)-8-[[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]Ergoline CAS NO 1075250-74-6 is a key protected intermediate in the synthesis of complex ergot alkaloids and related pharmaceutical compounds. Its primary value lies in providing a stable, silyl-protected hydroxyl group, enabling precise and selective downstream chemical transformations critical for modern drug development. This high-purity intermediate is essential for research and production facilities in the pharmaceutical and fine chemical sectors, particularly those developing central nervous system (CNS) agents and other specialized therapeutics.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of ergoline-based active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for the discovery and optimization of novel therapeutic compounds targeting neurological pathways.
• Fine Chemical Synthesis: Serves as a versatile precursor in multi-step organic syntheses requiring protected functional groups.
• Process Chemistry: Employed in the scale-up and manufacturing of complex molecules for clinical and commercial supply.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development.

Basic Information

Item	Details
Product Name	(8β)-8-[[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]Ergoline
CAS No.	1075250-74-6
Molecular Formula	C21H33NO2Si
Molecular Weight	359.58 g/mol
Synonyms	8-((tert-Butyldimethylsilyloxy)methyl)ergoline; TBDMS-protected 8-hydroxymethylergoline; 8-(Hydroxymethyl)ergoline TBDMS ether; (8β)-8-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]ergoline; tert-Butyldimethylsilyl 8-ergolinylmethyl ether; 8-((tert-Butyldimethylsilyl)oxymethyl)ergoline; 8β-[[(tert-Butyldimethylsilyl)oxy]methyl]ergoline
EINECS	Contact for details

Quality Control

Our (8β)-8-[[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]Ergoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques including HPLC, GC, and NMR. We adhere to cGMP principles where applicable to meet the stringent requirements of pharmaceutical development and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Single Maximum Impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.