Description

(8β)-9,10-Didehydro-8-[[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]-6-Methylergoline CAS NO 1075250-72-4 is a key, high-purity synthetic intermediate in advanced pharmaceutical research and development. This compound is valued for its role as a protected precursor in the synthesis of complex ergoline alkaloids and related active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of specialized therapeutics, where precise chemical structure and high purity are critical for successful outcomes.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel ergot alkaloid derivatives and APIs.
• Neurology & Psychiatry Drug Research: Used in the development of potential therapeutics targeting serotonin and dopamine receptor pathways.
• Migraine Treatment R&D: Serves as a precursor in the synthesis of new-generation triptan analogs and related compounds.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale production of advanced intermediates.
• Academic & Institutional Research: Utilized in medicinal chemistry programs for structure-activity relationship (SAR) studies.
• Reference Standard: Can be supplied as a high-purity compound for analytical method development and validation.

Basic Information

Product Name	(8β)-9,10-Didehydro-8-[[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]-6-Methylergoline
CAS No.	1075250-72-4
Molecular Formula	C24H36N2O2Si
Molecular Weight	412.65 g/mol
Synonyms	8-((tert-Butyldimethylsilyloxy)methyl)-6-methyl-8,9-didehydroergoline; 8β-[(tert-Butyldimethylsilyloxy)methyl]-6-methylergoline-8,9-diene; TBDMS-protected 8-hydroxymethyl-6-methylergoline derivative; 6-Methyl-8,9-didehydroergoline-8β-methanol TBDMS ether; (8β)-9,10-Didehydro-8-(((tert-butyldimethylsilyl)oxy)methyl)-6-methylergoline; 8β-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl-6-methyl-δ8,9-ergoline; TBDMS-8-CH2OH-6-Me-ergoline
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity suitable for research and development. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support compliance with cGMP guidelines for pharmaceutical intermediates where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is sensitive to fluoride and strong alkali; ensure it is stored separately from such materials. For long-term storage, consider keeping the container under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area %)	≥ 98.0%
Single Maximum Impurity	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.