Description

8-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline Hydrochloride is a high-purity, advanced pharmaceutical intermediate and versatile organic building block. This compound is valued for its unique trifluoromethylated isoquinoline scaffold, which is critical for modulating the pharmacokinetic and binding properties of bioactive molecules. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel drug candidates and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of central nervous system (CNS) active agents, kinase inhibitors, and other therapeutic small molecules.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the trifluoromethyl group enhances biological activity and stability.
• Material Science Precursor: Serves as a monomer or functionalizing agent for creating specialty polymers and advanced organic materials.
• Chemical Biology & Proteomics: Employed as a molecular scaffold or tag in probe development for studying biological pathways and protein interactions.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological development and exploratory synthetic chemistry.
• Fluorine Chemistry: A valuable reagent for introducing the trifluoromethyl group into complex molecular architectures.

Basic Information

Product Name	8-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline Hydrochloride
CAS No.	1074764-70-7
Molecular Formula	C10H10F3N·HCl
Molecular Weight	237.65 g/mol
Synonyms	8-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline HCl; 8-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride; 1,2,3,4-Tetrahydro-8-(trifluoromethyl)isoquinoline hydrochloride; 8-Trifluoromethyl-1,2,3,4-tetrahydroisoquinoline HCl; 8-CF3-THIQ·HCl
EINECS	Contact for details

Quality Control

Our 8-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline Hydrochloride is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and industry best practices for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.