Description

5-(o-Tbdms)Oxymethylfuran-2-Boronic Acid CAS NO 1072952-55-6 is a high-value, protected boronic acid derivative used as a key synthetic intermediate in advanced organic synthesis. Its primary commercial value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern pharmaceutical and agrochemical manufacturing. This compound is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and materials science industries who require reliable, high-purity building blocks for complex molecule assembly.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in constructing complex heterocyclic cores found in drug candidates.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require furan-based architectures.
• Material Science Research: Serves as a monomer or precursor for developing advanced polymers, ligands, and organic electronic materials with tailored properties.
• Suzuki-Miyaura Cross-Coupling: The quintessential application, where it acts as the organoboron reagent to form biaryl and other C-C bonds with high efficiency and functional group tolerance.
• Protecting Group Strategy: The *tert*-butyldimethylsilyl (TBDMS) protecting group allows for selective manipulation of other functional groups during multi-step syntheses.
• Chemical Biology & Probe Development: Utilized in creating molecular probes and labeled compounds for biochemical research and diagnostic applications.

Basic Information

Product Name	5-(o-Tbdms)Oxymethylfuran-2-Boronic Acid
CAS No.	1072952-55-6
Molecular Formula	C12H21BO4Si
Molecular Weight	268.19 g/mol
Synonyms	5-[(tert-Butyldimethylsilyl)oxymethyl]furan-2-boronic Acid; 5-((tert-Butyldimethylsilyloxy)methyl)furan-2-boronic Acid; 5-[(TBDMS)oxymethyl]-2-furanboronic Acid; 2-Furanboronic acid, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-; 5-(TBDMSoxymethyl)furan-2-ylboronic Acid; 5-OTBDMS-Methylfuran-2-Boronic Acid
EINECS	Contact for details

Quality Control

Every batch of 5-(o-Tbdms)Oxymethylfuran-2-Boronic Acid is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive coupling reactions and regulatory filings. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC/NMR), identity confirmation, and impurity profiles. Our quality commitment supports applications in cGMP and ISO-certified environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C (refrigerated) for optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95.0% (Area %)
Assay (NMR)	≥90.0%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.