Description

5-((tert-Butoxycarbonylamino)Methyl)Thiophen-2-Ylboronic Acid is a high-purity, advanced pharmaceutical intermediate and building block for organic synthesis. This compound is valued for its role in facilitating efficient cross-coupling reactions, enabling the construction of complex molecular architectures. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing thiophene and boronic acid functionalities.
• Suzuki-Miyaura Cross-Coupling: Serves as a critical boronic acid reagent for palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds, essential for creating complex organic molecules.
• Agrochemical Research: Used in the research and development of new herbicides, fungicides, and insecticides that require specific heterocyclic structures.
• Material Science: Employed in the synthesis of organic electronic materials, such as polymers and small molecules for OLEDs and semiconductors.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the development of chemical probes and inhibitors.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-fidelity boronic acid derivatives.

Basic Information

Product Name	5-((tert-Butoxycarbonylamino)Methyl)Thiophen-2-Ylboronic Acid
CAS No.	1072951-39-3
Molecular Formula	C11H18BNO4S
Molecular Weight	271.14 g/mol
Synonyms	5-((tert-Butoxycarbonylamino)methyl)thiophene-2-boronic acid; 2-Thiopheneboronic acid, 5-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-; 5-((Boc-amino)methyl)thiophene-2-boronic acid; 5-(Boc-aminomethyl)thiophen-2-ylboronic acid; Boc-NH-CH2-Thiophene-2-B(OH)2; N-Boc-2-aminomethyl-5-thienylboronic acid; tert-Butyl N-[(5-borono-2-thienyl)methyl]carbamate
EINECS	Contact for details

Quality Control

Our 5-((tert-Butoxycarbonylamino)Methyl)Thiophen-2-Ylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.