Description

1-(6-Chloropyrimidin-4-Yl)Pyrazole-4-Boronic Acid is a high-purity boronic acid derivative and a critical building block in modern synthetic chemistry. Its value lies in enabling the precise construction of complex heterocyclic molecules through efficient cross-coupling reactions. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in creating novel herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science: Serves as a building block for organic electronic materials, such as those used in OLEDs and sensors.
• Suzuki-Miyaura Cross-Coupling: The boronic acid functional group makes it an ideal partner for palladium-catalyzed cross-coupling reactions to form biaryl and heterobiaryl structures.
• Chemical Biology & Proteomics: Employed in the development of molecular probes and tools for studying biological pathways.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	1-(6-Chloropyrimidin-4-Yl)Pyrazole-4-Boronic Acid
CAS No.	1072945-81-3
Molecular Formula	C7H6BClN4O2
Molecular Weight	224.41 g/mol
Synonyms	1-(6-Chloro-4-pyrimidinyl)-1H-pyrazole-4-boronic acid; (1-(6-Chloropyrimidin-4-yl)-1H-pyrazol-4-yl)boronic acid; 1-(6-Chloropyrimidin-4-yl)-1H-pyrazole-4-boronic acid pinacol ester (common protected form); 4-(4-Borono-1H-pyrazol-1-yl)-6-chloropyrimidine; 6-Chloro-4-(4-boronopyrazol-1-yl)pyrimidine; 1-(6-Chloro-pyrimidin-4-yl)-1H-pyrazole-4-boronic acid; B-[1-(6-Chloro-4-pyrimidinyl)-1H-pyrazol-4-yl]-Boranedicarboxylic Acid
EINECS	Contact for details

Quality Control

Our 1-(6-Chloropyrimidin-4-Yl)Pyrazole-4-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency suitable for demanding R&D and scale-up processes. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.