Description

4-Methoxycarbonyl-1H-Indole-2-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. Its core value lies in its role as a key precursor in the synthesis of complex molecules, particularly through Suzuki-Miyaura cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality boronic ester reagents for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel indole-based active pharmaceutical ingredients (APIs) and drug candidates.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boronic ester component for forming carbon-carbon bonds, enabling the construction of complex molecular architectures.
• Drug Discovery & Medicinal Chemistry: Used in high-throughput screening and the development of targeted therapies, including kinase inhibitors and other small molecule drugs.
• Agrochemical Research: Employed in the synthesis of new crop protection agents and herbicides with indole scaffolds.
• Material Science & Organic Electronics: A precursor for creating functional organic materials, such as organic light-emitting diodes (OLEDs) and conductive polymers.
• Chemical Biology & Proteomics: Utilized in the development of molecular probes and tools for studying biological systems.

Basic Information

Product Name	4-Methoxycarbonyl-1H-Indole-2-Boronic Acid Pinacol Ester
CAS No.	1072811-67-6
Molecular Formula	C₁₆H₂₀BNO₄
Molecular Weight	301.15 g/mol
Synonyms	Methyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-4-carboxylate; 1H-Indole-4-carboxylic acid, 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester; 4-(Methoxycarbonyl)-1H-indole-2-boronic acid pinacol ester; 2-Borono-1H-indole-4-carboxylic acid methyl ester pinacol ester; Indole-2-boronic acid pinacol ester, 4-methoxycarbonyl derivative
EINECS	Contact for details

Quality Control

Our 4-Methoxycarbonyl-1H-Indole-2-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC, Area%)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.