Description

2-Bromo-4,6-Difluoro-3'-Methyl-1,1'-Biphenyl is a high-purity, multi-substituted biphenyl derivative that serves as a critical building block in advanced organic synthesis. Its precise halogen and fluorine substitution pattern makes it an invaluable intermediate for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and functional materials. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for their R&D and production processes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting complex heterocycles and receptor ligands.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the difluoro and bromo substituents contribute to biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a core structural unit in the production of specialty materials for electronic displays and organic light-emitting diodes (OLEDs) due to its rigid biphenyl backbone.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create more complex biaryl systems.
• Functional Material Research: Employed in academic and industrial R&D for creating novel polymers, ligands for catalysis, and other functional organic compounds.
• Chemical Reference Standard: Used as a certified reference material (CRM) for analytical method development and quality control in chemical manufacturing.

Basic Information

Product Name	2-Bromo-4,6-Difluoro-3'-Methyl-1,1'-Biphenyl
CAS No.	1071866-13-1
Molecular Formula	C₁₃H₉BrF₂
Molecular Weight	283.11 g/mol
Synonyms	3'-Methyl-2-bromo-4,6-difluorobiphenyl; 1,1'-Biphenyl, 2-bromo-4,6-difluoro-3'-methyl-; 2-Bromo-4,6-difluoro-3'-methylbiphenyl; Biphenyl, 2-bromo-4,6-difluoro-3'-methyl-; [1,1'-Biphenyl]-2-bromo-4,6-difluoro-3'-methyl
EINECS	Contact for details

Quality Control

Our 2-Bromo-4,6-Difluoro-3'-Methyl-1,1'-Biphenyl is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification parameters. Our quality commitment aligns with cGMP principles where applicable, ensuring the material is suitable for demanding applications in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to prevent contamination and moisture absorption. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.