Description

4-Fluorobenzoyl-D4 Chloride is a deuterated derivative of 4-fluorobenzoyl chloride, where four hydrogen atoms are replaced by deuterium, serving as a stable isotope-labeled reagent. This compound is critically important for use as an internal standard in quantitative mass spectrometry, ensuring high accuracy and precision in analytical measurements. It is primarily needed by pharmaceutical research and development laboratories, agrochemical companies, and analytical service providers working on method development for pharmacokinetic studies, metabolic profiling, and environmental fate analysis.

Application

• Internal Standard for LC-MS/MS: Essential for the accurate quantification of 4-fluorobenzoyl chloride and related metabolites in complex biological matrices.
• Pharmaceutical Research: Used in the synthesis and analysis of deuterated drug candidates for improved metabolic stability and pharmacokinetic studies.
• Metabolite Identification: Aids in the detection and structural elucidation of drug metabolites in in vitro and in vivo studies.
• Agrochemical Analysis: Employed in residue analysis and environmental monitoring studies for fluorinated pesticides and herbicides.
• Forensic Toxicology: Supports precise measurement of specific analytes in forensic investigations requiring isotopic dilution techniques.
• Chemical Synthesis Intermediate: Acts as a specialized building block for introducing a deuterated 4-fluorobenzoyl moiety into more complex molecules.

Basic Information

Product Name	4-Fluorobenzoyl-D4 Chloride
CAS No.	1071809-52-3
Molecular Formula	C7D4ClFO
Molecular Weight	160.57 g/mol (deuterated form)
Synonyms	4-Fluorobenzoyl-d4 Chloride; p-Fluorobenzoyl-d4 Chloride; 2,3,5,6-Tetradeutero-4-fluorobenzoyl Chloride; [2,3,5,6-2H4]-4-Fluorobenzoyl Chloride; Deutero-p-Fluorobenzoyl Chloride; 4-Fluoro(deuterobenzoyl) Chloride; Benzoyl-d4 chloride, 4-fluoro-; (2,3,5,6-Tetradeuterio-4-fluorophenyl)methanoyl chloride
EINECS	Contact for details

Quality Control

Our 4-Fluorobenzoyl-D4 Chloride is manufactured under strict quality systems to ensure the high isotopic purity and chemical integrity required for analytical applications. Each batch undergoes comprehensive analysis, including NMR, HPLC, and mass spectrometry, to confirm deuterium incorporation and chemical purity. Certificates of Analysis (COA) detailing isotopic enrichment (typically >98 atom % D), chemical purity, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and moisture-sensitive nature, it is recommended to handle and store the material under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.