Description

Iloperidone-D3 is a deuterated isotopologue of the atypical antipsychotic Iloperidone, specifically labeled with three deuterium atoms. This stable isotope-labeled compound is a critical reference standard and internal standard for the precise quantification and pharmacokinetic studies of Iloperidone in complex biological matrices. It is essential for researchers and quality control laboratories in the pharmaceutical and analytical chemistry sectors who require high-fidelity analytical data for method development, validation, and regulatory compliance.

Application

• Primary use as an Internal Standard for the accurate quantification of Iloperidone via Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and Gas Chromatography-Mass Spectrometry (GC-MS).
• Critical component in Pharmacokinetic and Metabolism Studies to track the absorption, distribution, metabolism, and excretion (ADME) profile of the parent drug.
• Reference material for Bioanalytical Method Development and Validation in accordance with FDA, EMA, and ICH guidelines.
• Used in Drug Impurity Profiling and Degradation Studies to identify and characterize related substances.
• Essential for Clinical Research and Therapeutic Drug Monitoring (TDM) programs to ensure accurate patient dosing.
• High-purity material for use in Certified Reference Material (CRM) production for laboratory accreditation and quality assurance.

Basic Information

Product Name	Iloperidone-D3
CAS No.	1071168-82-5
Molecular Formula	C24H24D3FN2O4
Molecular Weight	429.50 g/mol (for C24H24D3FN2O4)
Synonyms	1-[4-[3-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone-d3; Iloperidone (phenyl-d3); 4'-[3-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3'-methoxyacetophenone-d3; Fanapt-D3; Zomaril-D3; Deuterated Iloperidone; Iloperidone Internal Standard
EINECS	Contact for details

Quality Control

Every batch of Iloperidone-D3 is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. Our products undergo rigorous quality testing to ensure compliance with industry standards for stable isotope-labeled compounds. Certificates of Analysis (COA) are available upon request, providing detailed results for identity, chemical purity, isotopic purity (enrichment), and chromatographic profile.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. The product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Enrichment)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.