Description

Glycodeoxycholic-2,2,4,4-D4 Acid is a deuterium-labeled analog of the primary bile acid glycodeoxycholic acid, serving as a critical internal standard and tracer in advanced analytical and metabolic research. This high-purity, isotopically labeled compound is essential for ensuring accuracy and precision in quantitative mass spectrometry analyses, particularly in studies of bile acid metabolism and enterohepatic circulation. It is primarily utilized by pharmaceutical R&D laboratories, clinical research organizations, and academic institutions focused on hepatology, gastroenterology, and metabolomics.

Application

• Quantitative Mass Spectrometry: Used as a stable isotope-labeled internal standard for the precise quantification of endogenous glycodeoxycholic acid and related bile acids in biological matrices (plasma, serum, urine, feces).
• Metabolic Pathway Tracing: Enables detailed investigation of bile acid synthesis, conjugation, and enterohepatic recycling in preclinical and clinical studies.
• Drug Metabolism & Pharmacokinetics (DMPK): Facilitates the study of drug-bile acid interactions and the assessment of drug-induced liver injury (DILI) in pharmaceutical development.
• Diagnostic Assay Development: Critical component in the development and validation of LC-MS/MS clinical diagnostic kits for hepatobiliary diseases.
• Biomarker Discovery & Validation: Supports metabolomics research aimed at identifying and validating bile acid signatures associated with specific disease states.
• Quality Control Reference Standard: Serves as a certified reference material (CRM) for quality assurance in analytical laboratories.

Basic Information

Item	Details
Product Name	Glycodeoxycholic-2,2,4,4-D4 Acid
CAS No.	1069132-37-1
Molecular Formula	C₂₆H₄₀D₄NO₅
Molecular Weight	Contact for details
Synonyms	N-[(3α,5β,12α)-3,12-Dihydroxy-24-oxocholan-24-yl]glycine-2,2,4,4-d4; Deuterated Glycodeoxycholic Acid; Glycochenodeoxycholic Acid-d4 (common misnomer); GDCA-d4; GDC-d4; N-(3α,12α-Dihydroxy-5β-cholan-24-oyl)glycine-2,2,4,4-d4; 3α,12α-Dihydroxy-5β-cholan-24-oyl glycine-2,2,4,4-d4
EINECS	Contact for details

Quality Control

Every batch of Glycodeoxycholic-2,2,4,4-D4 Acid is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, verified by advanced spectroscopic and chromatographic techniques including NMR, HPLC, and LC-MS. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and analytical results is provided with each shipment to ensure traceability and compliance with your research or quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (by NMR)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.