Description

L-Proline,4-Mercoptan-,Hydrochloride(1:1),(4R)- is a high-purity, non-proteinogenic amino acid derivative of significant interest in advanced pharmaceutical research and development. This chiral compound, with its unique proline backbone and thiol functional group, serves as a critical building block for the synthesis of complex bioactive molecules and peptide mimetics. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, particularly for developing enzyme inhibitors, constrained peptides, and novel therapeutic agents targeting various disease pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for protease inhibitors and other enzyme-targeted therapies.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce conformational constraints and enhance metabolic stability of peptide-based drug candidates.
• Bioconjugation & Probe Development: The reactive thiol (mercapto) group enables site-specific bioconjugation for creating antibody-drug conjugates (ADCs), fluorescent probes, and diagnostic agents.
• Chemical Biology Research: Employed as a tool compound to study enzyme mechanisms, protein-protein interactions, and to develop activity-based probes for proteomics.
• Asymmetric Synthesis Catalyst: Can serve as a precursor or component in chiral organocatalysts for stereoselective organic transformations.

Basic Information

Product Name	L-Proline,4-Mercapto-,Hydrochloride(1:1),(4R)-
CAS No.	1067189-36-9
Molecular Formula	C5H9NO2S • HCl
Molecular Weight	183.66 g/mol
Synonyms	(4R)-4-Mercapto-L-proline hydrochloride; (2S,4R)-4-Mercaptoproline hydrochloride; 4-Thia-L-proline hydrochloride; 4-Mercapto-L-proline HCl; L-4-Mercaptoproline hydrochloride; (4R)-4-Sulfanyl-L-proline hydrochloride; 4-SH-L-Pro•HCl
EINECS	Contact for details

Quality Control

Our L-Proline,4-Mercapto-,Hydrochloride(1:1),(4R)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the exacting standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) providing batch-specific results for identity, purity, and related substances is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and easily oxidized nature. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.