Description

Bosentan-D4 is a deuterated isotopologue of the dual endothelin receptor antagonist Bosentan, specifically labeled with four deuterium atoms. This stable isotope-labeled compound is an essential internal standard for the precise quantification of Bosentan in biological matrices using advanced analytical techniques like LC-MS/MS. It is a critical tool for researchers and quality control laboratories in the pharmaceutical industry, enabling accurate pharmacokinetic studies, drug metabolism research, and ensuring the reliability of bioanalytical methods.

Application

• Bioanalytical Reference Standard: Primary use as an internal standard for the quantification of Bosentan in plasma, serum, and other biological samples via mass spectrometry.
• Pharmacokinetic & Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Method Development & Validation: Serves as a critical component in developing and validating robust, GLP-compliant LC-MS/MS assays for pharmaceutical analysis.
• Drug Impurity Profiling: Used in stability studies and impurity characterization to understand degradation pathways of the parent drug substance.
• Forensic & Doping Control Analysis: Supports accurate detection and confirmation of Bosentan in specialized testing scenarios.

Basic Information

Product Name	Bosentan-D4
CAS No.	1065472-77-6
Molecular Formula	C27H25D4N5O6S
Molecular Weight	~ 555.62 g/mol
Synonyms	Bosentan-d4; 4-tert-Butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]benzenesulfonamide-d4; Tracleer-d4; Ro 47-0203-d4; (2,3,4,5-D4)-Bosentan; Deuterated Bosentan (4-D); Endothelin Receptor Antagonist-d4
EINECS	Contact for details

Quality Control

Every batch of Bosentan-D4 is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to support your research and regulatory submissions. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing isotopic purity, chemical purity, and confirming identity and strength.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label/COA. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.