Description

Hydroxyisovaleroyl-D3 Carnitine is a stable isotope-labeled derivative of L-carnitine, specifically deuterated at three positions. This compound is of significant value as a high-purity internal standard and reference material for quantitative mass spectrometry analysis in biomedical research. It is essential for researchers and manufacturers in the pharmaceutical, clinical diagnostics, and nutritional science industries who require precise measurement of carnitine and its metabolites in complex biological matrices.

Application

• Internal Standard for LC-MS/MS: Used for the accurate quantification of L-carnitine and related acylcarnitines in bioanalytical methods.
• Metabolomics Research: A critical tool in metabolic pathway studies, particularly for investigating disorders of fatty acid oxidation and mitochondrial function.
• Clinical Diagnostics: Employed in the development and validation of assays for inborn errors of metabolism, such as primary carnitine deficiency.
• Pharmaceutical Development: Serves as a reference standard in pharmacokinetic and pharmacodynamic studies of carnitine-based therapeutics.
• Nutritional Science Research: Used to trace and quantify carnitine uptake, metabolism, and excretion in nutritional studies.
• Quality Control: Acts as a certified reference material for ensuring the accuracy and consistency of analytical results in testing laboratories.

Basic Information

Product Name	Hydroxyisovaleroyl-D3 Carnitine
CAS No.	1058636-00-2
Molecular Formula	C12H20D3NO5
Molecular Weight	262.33 g/mol (for monoisotopic mass)
Synonyms	(R)-3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium, 3-[(3-methyl-1-oxobutyl-d3)oxy]-, inner salt; L-Carnitine 3-hydroxy-3-methylbutyrate-d3; 3-Hydroxyisovalerylcarnitine-d3; HMB-carnitine-d3; 3-Hydroxy-3-methylbutyryl-L-carnitine-d3; Deuterated Hydroxyisovaleryl Carnitine; Stable Isotope-Labeled Acylcarnitine
EINECS	Contact for details

Quality Control

Our Hydroxyisovaleroyl-D3 Carnitine is manufactured under strict quality systems to ensure the highest standards of isotopic purity and chemical identity, critical for its use as a reference material. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (D3, atom % D), chemical purity (by HPLC), and confirmation of structure (by NMR and MS). We adhere to relevant guidelines for reference standards to support GLP and ISO 17025 compliant laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 98.0% (D3)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.