Description

Methyl 4-(Hydroxymethyl)-1,2-Dimethyl-5-(2-Thienyl)-2-Pyrrolidinecarboxylate is a high-purity, advanced pharmaceutical intermediate with a complex pyrrolidine-thiophene hybrid structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities and proprietary drug candidates.

Application

• Pharmaceutical Intermediate: Key building block in the research and synthesis of novel drug candidates targeting central nervous system (CNS) disorders, inflammation, and other therapeutic areas.
• Organic Synthesis Reagent: Used in academic and industrial R&D for constructing complex nitrogen-containing heterocycles, leveraging its functionalized pyrrolidine core.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Precursor for Chiral Compounds: Potential use in the synthesis of enantiomerically pure molecules due to its chiral centers, applicable in asymmetric synthesis.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for cGMP production of clinical trial materials.
• Chemical Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	Methyl 4-(Hydroxymethyl)-1,2-Dimethyl-5-(2-Thienyl)-2-Pyrrolidinecarboxylate
CAS No.	1052612-49-3
Molecular Formula	C13H19NO3S
Molecular Weight	269.36 g/mol
Synonyms	Methyl 4-(hydroxymethyl)-1,2-dimethyl-5-(thiophen-2-yl)pyrrolidine-2-carboxylate; 2-Pyrrolidinecarboxylic acid, 4-(hydroxymethyl)-1,2-dimethyl-5-(2-thienyl)-, methyl ester; 1,2-Dimethyl-4-(hydroxymethyl)-5-(2-thienyl)pyrrolidine-2-carboxylic acid methyl ester; 5-(2-Thienyl)-4-(hydroxymethyl)-1,2-dimethyl-2-pyrrolidinecarboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 4-(Hydroxymethyl)-1,2-Dimethyl-5-(2-Thienyl)-2-Pyrrolidinecarboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP applications. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.