Description

Nevirapine-D4 CAS NO 1051418-95-1 is a deuterated internal standard of the non-nucleoside reverse transcriptase inhibitor (NNRTI) Nevirapine, where four hydrogen atoms are replaced by deuterium. This stable isotope-labeled compound is essential for ensuring the accuracy and reliability of quantitative bioanalytical methods, particularly in pharmacokinetic and metabolism studies. It is a critical tool for pharmaceutical researchers, analytical laboratories, and contract research organizations (CROs) involved in the development and quality control of antiviral medications.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the precise quantification of Nevirapine in biological matrices such as plasma, serum, and tissue homogenates.
• Pharmacokinetic (PK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Drug Metabolism Studies: Used in metabolite identification and profiling to understand the metabolic pathways and stability of Nevirapine.
• Method Development & Validation: A key component in developing and validating robust, regulatory-compliant analytical methods for Good Laboratory Practice (GLP) and clinical trials.
• Quality Control & Assurance: Supports impurity profiling and assay verification in pharmaceutical manufacturing to ensure batch-to-batch consistency and purity of the active pharmaceutical ingredient (API).
• Forensic & Clinical Toxicology: Assists in the accurate measurement of drug levels for therapeutic drug monitoring or forensic investigations.

Basic Information

Product Name	Nevirapine-D4
CAS No.	1051418-95-1
Molecular Formula	C15H10D4N4O
Molecular Weight	270.32 g/mol
Synonyms	Nevirapine-d4; 11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one-d4; 11-Cyclopropyl-4-methyl-5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one-d4; Deuterated Nevirapine; Nevirapine (tetradeuterated); BI-RG-587-d4; NVP-d4; Viramune-d4
EINECS	Contact for details

Quality Control

Our Nevirapine-D4 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, isotopic enrichment, and structural integrity. We provide comprehensive Certificates of Analysis (COA) detailing purity (by HPLC), isotopic purity (by MS), and other critical parameters. Our quality commitment supports compliance with the stringent requirements of pharmaceutical R&D and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.