Description

n-(6-Chloro-9H-Pyrido[3,4-B]Indol-8-Yl)-3-Pyridinecarboxamide Dihydrochloride is a high-purity, non-natural β-carboline derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate and a versatile scaffold for the design of novel bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, particularly for the investigation of neurological and oncological targets.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates targeting specific enzyme pathways.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Biochemical Tool Compound: Employed in vitro to study protein-ligand interactions and cellular signaling mechanisms.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Preclinical Development: Supplied for early-stage pharmacological and toxicological evaluation of new chemical entities.

Basic Information

Product Name	n-(6-Chloro-9H-Pyrido[3,4-B]Indol-8-Yl)-3-Pyridinecarboxamide Dihydrochloride
CAS No.	1049743-58-9
Molecular Formula	C₁₇H₁₂ClN₄O • 2HCl
Molecular Weight	406.68 g/mol
Synonyms	6-Chloro-8-[(pyridine-3-carbonyl)amino]-9H-pyrido[3,4-b]indole dihydrochloride; 3-Pyridinecarboxamide, N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)-, dihydrochloride; β-Carboline-8-carboxamide derivative; GSK-3 Inhibitor XIII (analog); Research Compound 1049743-58-9
EINECS	Contact for details

Quality Control

Our n-(6-Chloro-9H-Pyrido[3,4-B]Indol-8-Yl)-3-Pyridinecarboxamide Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the stringent requirements for research and development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.