Description

(R)-α-(3-Thiophenylmethyl)-Proline-Hcl CAS NO 1049732-20-8 is a high-purity chiral proline derivative, a critical building block in modern pharmaceutical synthesis. This compound is valued for its role in constructing complex molecular architectures with precise stereochemistry, essential for developing active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly in areas requiring advanced chiral intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in protease inhibitor and other targeted therapies.
• Asymmetric Synthesis: Used as a catalyst or auxiliary in stereoselective organic synthesis to induce desired chirality in final products.
• Peptidomimetics Research: Serves as a constrained proline analog in the design and synthesis of peptide-like molecules for drug discovery.
• Chemical Biology Probes: Employed in the development of specialized probes and ligands for studying biological systems and enzyme functions.
• Process Chemistry & Scale-up: Suitable for use in process optimization and pilot-scale manufacturing of advanced pharmaceutical intermediates.

Basic Information

Product Name	(R)-α-(3-Thiophenylmethyl)-Proline-Hcl
CAS No.	1049732-20-8
Molecular Formula	C11H15NO2S • HCl
Molecular Weight	261.77 g/mol (Free base: 225.31 g/mol)
Synonyms	(R)-α-[(3-Thienyl)methyl]-L-proline hydrochloride; (R)-α-(3-Thienylmethyl)proline hydrochloride; (R)-3-Thiophen-3-ylmethyl-pyrrolidine-2-carboxylic acid hydrochloride; (2R)-1-(3-Thiophenylmethyl)proline HCl; (R)-TMP-HCl; Proline, (R)-α-[(3-thienyl)methyl]-, hydrochloride; L-Proline, α-[(3-thienyl)methyl]-, hydrochloride, (αR)-
EINECS	Contact for details

Quality Control

Our (R)-α-(3-Thiophenylmethyl)-Proline-Hcl is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, chiral purity, and impurity profiles. Our quality system is designed to meet the stringent requirements of pharmaceutical intermediate supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.