Description

Methyl 1-Boc-6-Amino-Indole-2-Carboxylate CAS NO 1049677-82-8 is a high-purity, protected indole derivative serving as a critical building block in advanced organic synthesis. This compound is essential for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and biotechnology industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates targeting various therapeutic areas, including oncology and central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new bioactive molecules.
• Peptidomimetic Synthesis: Serves as a constrained amino acid surrogate for creating novel peptide analogs with enhanced stability and bioavailability.
• Agrochemical Development: Employed in the research and production of advanced crop protection agents and pesticides.
• Chemical Biology Probes: Utilized to create labeled compounds and molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up manufacturing under cGMP conditions.

Basic Information

Product Name	Methyl 1-Boc-6-Amino-Indole-2-Carboxylate
CAS No.	1049677-82-8
Molecular Formula	C16H20N2O4
Molecular Weight	304.34 g/mol
Synonyms	1-Boc-6-Amino-1H-indole-2-carboxylic acid methyl ester; Methyl 6-amino-1-[(tert-butoxy)carbonyl]-1H-indole-2-carboxylate; 1H-Indole-2-carboxylic acid, 6-amino-1-[(1,1-dimethylethoxy)carbonyl]-, methyl ester; tert-Butyl 6-amino-2-(methoxycarbonyl)-1H-indole-1-carboxylate; 6-Amino-1-Boc-indole-2-carboxylic acid methyl ester; Methyl 1-(tert-butoxycarbonyl)-6-aminoindole-2-carboxylate; 1-Boc-6-NH2-indole-2-COOMe
EINECS	Contact for details

Quality Control

Our Methyl 1-Boc-6-Amino-Indole-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can adhere to relevant standards for advanced intermediates, supporting our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is moisture-sensitive (hygroscopic); therefore, containers should be kept sealed under an inert atmosphere when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.