Description

3,3-Dimethyl-6-Nitro-2,3-Dihydro-Indole-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its specific indole-based molecular scaffold. This compound matters as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), enabling the development of novel therapeutic agents. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in medicinal chemistry, particularly for projects involving kinase inhibitors or other nitrogen-containing heterocyclic targets.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of novel drug candidates, especially in oncology and CNS research.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Synthesis: Serves as a protected intermediate for further functionalization of the indole nitrogen and carboxylic acid groups.
• API Development: Employed in the pilot-scale and commercial-scale production of target active pharmaceutical ingredients requiring this specific molecular framework.
• Reference Standard: Utilized as an analytical standard for quality control and method development in pharmaceutical manufacturing.

Basic Information

Product Name	3,3-Dimethyl-6-Nitro-2,3-Dihydro-Indole-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1049677-52-2
Molecular Formula	C15H18N2O4
Molecular Weight	290.32 g/mol
Synonyms	1-Boc-3,3-dimethyl-6-nitroindoline; tert-Butyl 3,3-dimethyl-6-nitro-2,3-dihydro-1H-indole-1-carboxylate; 6-Nitro-1-Boc-3,3-dimethylindoline; 1H-Indole-1-carboxylic acid, 2,3-dihydro-3,3-dimethyl-6-nitro-, 1,1-dimethylethyl ester; 3,3-Dimethyl-6-nitroindoline-1-carboxylic acid tert-butyl ester; Boc-3,3-dimethyl-6-nitroindoline
EINECS	Contact for details

Quality Control

Our 3,3-Dimethyl-6-Nitro-2,3-Dihydro-Indole-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and incompatible materials. For long-term storage, consider an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.