Description

1-Boc-6-Amino-3,3-Dimethyl-2-Oxo-2,3-Dihydro-Indole is a high-purity, protected indole derivative serving as a critical building block in advanced organic synthesis. Its value lies in providing a versatile and reactive amino group, protected by the acid-labile tert-butoxycarbonyl (Boc) group, for the controlled construction of complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Peptide Mimetics & Conjugate Chemistry: Used to incorporate the indole scaffold into peptide backbones or create drug-linker conjugates for targeted therapies.
• Agrochemical Research: Serves as a precursor in the development of new herbicides, fungicides, and plant growth regulators with enhanced efficacy.
• Material Science: Employed in the synthesis of organic semiconductors, dyes, and photostable polymers due to its robust heterocyclic structure.
• Academic & R&D Laboratories: A valuable reagent for methodological studies in synthetic organic chemistry and medicinal chemistry programs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the scalable production of client-specific target molecules under cGMP conditions where required.

Basic Information

Product Name	1-Boc-6-Amino-3,3-Dimethyl-2-Oxo-2,3-Dihydro-Indole
CAS No.	1049677-44-2
Molecular Formula	C15H20N2O3
Molecular Weight	276.33 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-6-amino-3,3-dimethylindolin-2-one; 6-Amino-3,3-dimethyl-2-oxoindoline-1-carboxylic acid tert-butyl ester; tert-Butyl 6-amino-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indole-1-carboxylate; N-Boc-6-amino-3,3-dimethyloxindole; Boc-6-Amino-3,3-dimethyloxindole; 1-Boc-6-amino-3,3-dimethyloxindole; 1049677-44-2
EINECS	Contact for details

Quality Control

Our 1-Boc-6-Amino-3,3-Dimethyl-2-Oxo-2,3-Dihydro-Indole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with full traceability are provided for every shipment. We support development and commercial projects requiring compliance with ICH guidelines and can supply material suitable for use under cGMP conditions upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.