Description

1-(6,7-Dimethoxy-3,4-Dihydroisoquinolin-2(1H)-Yl)-3-[2-Methyl-4-(Thiophen-2-Yl)-1,3-Thiazol-5-Yl]Propan-1-One is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for research and development in medicinal chemistry, offering a sophisticated building block for novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers targeting neurological and oncological pathways.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production.
• Academic Research: Utilized in university and institutional labs for pharmacological and biochemical studies.
• Preclinical Development: Serves as a critical material for producing compounds for in vitro and in vivo testing.
• Chemical Library Synthesis: A valuable scaffold for creating diverse compound libraries for high-throughput screening.

Basic Information

Product Name	1-(6,7-Dimethoxy-3,4-Dihydroisoquinolin-2(1H)-Yl)-3-[2-Methyl-4-(Thiophen-2-Yl)-1,3-Thiazol-5-Yl]Propan-1-One
CAS No.	1049132-14-0
Molecular Formula	C22H24N2O3S2
Molecular Weight	428.57 g/mol
Synonyms	1049132-14-0; 1-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)-3-[2-methyl-4-(thiophen-2-yl)-1,3-thiazol-5-yl]propan-1-one; 2-[3-[2-Methyl-4-(thiophen-2-yl)-1,3-thiazol-5-yl]propanoyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline; 6,7-Dimethoxy-2-[3-[2-methyl-4-(2-thienyl)-5-thiazolyl]propionyl]-1,2,3,4-tetrahydroisoquinoline; THIQ-Thiazole Propanone Derivative
EINECS	Contact for details

Quality Control

Our 1-(6,7-Dimethoxy-3,4-Dihydroisoquinolin-2(1H)-Yl)-3-[2-Methyl-4-(Thiophen-2-Yl)-1,3-Thiazol-5-Yl]Propan-1-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.