Description

Ethyl 2-Piperazino-4-(Trifluoromethyl)-1,3-Thiazole-5-Carboxylate is a high-value, multi-functional heterocyclic building block characterized by its piperazine and trifluoromethyl-substituted thiazole core. This compound matters for its role as a critical intermediate in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) and anti-infective therapies. Pharmaceutical R&D departments, agrochemical innovators, and advanced material scientists need this precise chemical for developing next-generation compounds with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, especially in areas like antipsychotics, antidepressants, and antimicrobial agents.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and library synthesis due to its privileged piperazine and fluorinated thiazole scaffolds.
• Agrochemical Development: Serves as a building block for creating new fungicides or herbicides with improved efficacy and environmental profiles.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological targets and pathways.
• Advanced Material Synthesis: Potential precursor for specialty chemicals used in electronic materials or liquid crystals.

Basic Information

Product Name	Ethyl 2-Piperazino-4-(Trifluoromethyl)-1,3-Thiazole-5-Carboxylate
CAS No.	1048913-30-9
Molecular Formula	C11H14F3N3O2S
Molecular Weight	309.31 g/mol
Synonyms	Ethyl 2-(piperazin-1-yl)-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate; 5-Carboxyethyl-2-piperazino-4-trifluoromethylthiazole; 1,3-Thiazole-5-carboxylic acid, 2-(1-piperazinyl)-4-(trifluoromethyl)-, ethyl ester; 2-Piperazino-4-trifluoromethyl-1,3-thiazole-5-carboxylic acid ethyl ester; 1048913-30-9; Ethyl 2-piperazinyl-4-(trifluoromethyl)thiazole-5-carboxylate
EINECS	Contact for details

Quality Control

Our Ethyl 2-Piperazino-4-(Trifluoromethyl)-1,3-Thiazole-5-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.