Description

Methyl 4-Bromo-5-Chlorothiophene-2-Carboxylate is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound is valued for its reactive halogen substituents, which enable precise molecular construction in complex chemical architectures. It is primarily utilized by research and development chemists and process scale-up teams in the pharmaceutical and agrochemical industries to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and metabolic diseases.
• Agrochemical Synthesis: Serves as a critical building block for developing new-generation herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Material Science Research: Used in the development of organic electronic materials, such as conductive polymers and organic semiconductors for OLEDs and sensors, leveraging the thiophene core.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Negishi cross-coupling reactions due to the presence of the bromo substituent, facilitating carbon-carbon bond formation.
• Functional Dye & Pigment Chemistry: Employed in the synthesis of specialized dyes and pigments where the thiophene ring contributes to color stability and light-fastness.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	Methyl 4-Bromo-5-Chlorothiophene-2-Carboxylate
CAS No.	1047630-72-7
Molecular Formula	C7H4BrClO2S
Molecular Weight	267.53 g/mol
Synonyms	Methyl 4-bromo-5-chloro-2-thiophenecarboxylate; 4-Bromo-5-chlorothiophene-2-carboxylic acid methyl ester; 2-Thiophenecarboxylic acid, 4-bromo-5-chloro-, methyl ester; 5-Chloro-4-bromothiophene-2-carboxylic acid methyl ester; Methyl 5-chloro-4-bromothiophene-2-carboxylate; 4-Bromo-5-chloro-2-(methoxycarbonyl)thiophene
EINECS	Contact for details

Quality Control

Our production of Methyl 4-Bromo-5-Chlorothiophene-2-Carboxylate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for your critical syntheses. Each lot is fully characterized and undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment. We support compliance with REACH and other global regulatory frameworks as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.