Description

Benzyl 5-Chlorospiro[Indoline-3,4'-Piperidine]-1'-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic molecular architecture. This compound is of significant value for its role as a critical building block in the research and development of novel therapeutic agents, particularly in central nervous system (CNS) and oncology drug discovery pipelines. It is primarily sought by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in synthesizing complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of new chemical entities (NCEs) for clinical trials.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization, particularly for targets involving spirocyclic scaffolds.
• Protease Inhibitor Synthesis: Serves as a core structure in the synthesis of potential inhibitors for various protease enzymes.
• Kinase Inhibitor Development: Employed in the construction of novel kinase inhibitor candidates for oncology and inflammatory diseases.
• Chemical Biology Probes: Utilized to create specialized molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Scale-Up: A starting material for contract manufacturing organizations (CMOs) performing custom synthesis from gram to kilogram scale.

Basic Information

Item	Details
Product Name	Benzyl 5-Chlorospiro[Indoline-3,4'-Piperidine]-1'-Carboxylate
CAS No.	1041704-16-8
Molecular Formula	C20H19ClN2O2
Molecular Weight	354.83 g/mol
Synonyms	1'-[(Benzyloxy)carbonyl]-5-chlorospiro[indoline-3,4'-piperidine]; 5-Chloro-1'-(phenylmethoxy)carbonylspiro[1,3-dihydro-2H-indole-3,4'-piperidine]; Benzyl 5-chloro-2,3-dihydro-1'H-spiro[indole-3,4'-piperidine]-1'-carboxylate; 5-Chlorospiro[indoline-3,4'-piperidine]-1'-carboxylic acid benzyl ester; Spiro[indoline-3,4'-piperidine]-1'-carboxylic acid, 5-chloro-, benzyl ester
EINECS	Contact for details

Quality Control

Our Benzyl 5-Chlorospiro[Indoline-3,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.