Description

4-Chloro-1-(5-Fluoro-1H-Indol-3-Yl)-Butan-1-One is a high-purity, advanced pharmaceutical intermediate characterized by its indole-based molecular structure with chloro and fluoro substituents. This compound matters for its critical role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting neurological and oncological pathways. Pharmaceutical R&D departments and fine chemical manufacturers need it to develop and scale up production of novel therapeutic agents, where its precise structure enables specific molecular interactions.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of novel drug candidates, especially in central nervous system (CNS) and oncology research.
• Biochemical Research: Used as a reference standard or a probe in studying enzyme inhibition and receptor binding activities due to its specific indole scaffold.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of targeted therapies.
• Academic Research: Employed in university and institutional laboratories for medicinal chemistry projects and the development of new synthetic methodologies.
• Process Chemistry Development: Utilized for optimizing synthetic routes, scaling up reactions, and establishing robust purification protocols for API manufacturing.

Basic Information

Product Name	4-Chloro-1-(5-Fluoro-1H-Indol-3-Yl)-Butan-1-One
CAS No.	1039037-46-1
Molecular Formula	C₁₂H₁₁ClFNO
Molecular Weight	239.67 g/mol
Synonyms	4-Chloro-1-(5-fluoro-1H-indol-3-yl)butan-1-one; 1-(5-Fluoro-1H-indol-3-yl)-4-chlorobutan-1-one; 5-Fluoro-3-(4-chlorobutyryl)indole; 4-Chloro-1-(5-fluoroindol-3-yl)butanone; 1039037-46-1; Butan-1-one, 4-chloro-1-(5-fluoro-1H-indol-3-yl)-; 4-Chloro-1-(5-fluoro-1H-indol-3-yl)butan-1-one
EINECS	Contact for details

Quality Control

Our 4-Chloro-1-(5-Fluoro-1H-Indol-3-Yl)-Butan-1-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our commitment to quality supports compliance in research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.