Description

Methyl 2-(4-(1-(tert-Butoxycarbonyl)Piperidin-3-Yl)Phenyl)-2H-Indazole-7-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant importance in modern drug discovery and development. This compound serves as a critical building block for the synthesis of complex bioactive molecules, particularly those targeting specific protein-protein interactions or enzymatic pathways. It is primarily required by research institutions, contract research organizations (CROs), and pharmaceutical companies engaged in the development of novel therapeutic agents, especially within oncology and central nervous system (CNS) research.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel active pharmaceutical ingredients (APIs) for preclinical and clinical research.
• Medicinal Chemistry Research: Used as a core scaffold or derivatization point for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of bifunctional molecules for targeted protein degradation.
• Kinase Inhibitor Synthesis: Employed in the construction of indazole-based compounds, which are common pharmacophores in kinase inhibitor libraries for cancer therapy.
• Chemical Biology Probes: Utilized to create labeled or tagged molecules for studying biological pathways and target engagement in cellular assays.
• Custom Synthesis & Scale-Up: Supplied for custom manufacturing projects, from milligram-scale research to kilogram-scale process development under cGMP guidelines.

Basic Information

Product Name	Methyl 2-(4-(1-(tert-Butoxycarbonyl)Piperidin-3-Yl)Phenyl)-2H-Indazole-7-Carboxylate
CAS No.	1038915-90-0
Molecular Formula	C26H31N3O4
Molecular Weight	449.55 g/mol
Synonyms	7-Carbomethoxy-2-[4-[1-(tert-butoxycarbonyl)-3-piperidyl]phenyl]-2H-indazole; Methyl 2-[4-[1-(BOC)-3-piperidyl]phenyl]-2H-indazole-7-carboxylate; 2H-Indazole-7-carboxylic acid, 2-[4-[1-[(1,1-dimethylethoxy)carbonyl]-3-piperidinyl]phenyl]-, methyl ester; BOC-Protected Indazole-Piperidine Intermediate; tert-Butyl 3-[4-(7-(methoxycarbonyl)-2H-indazol-2-yl)phenyl]piperidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our Methyl 2-(4-(1-(tert-Butoxycarbonyl)Piperidin-3-Yl)Phenyl)-2H-Indazole-7-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures material consistency and reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere in a freezer (-20°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.