Description

tert-Butyl 4-Fluoroindoline-1-Carboxylate is a high-purity, fluorinated indoline derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for its utility as a versatile synthetic intermediate.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of new-generation pesticides and herbicides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Chemical Research: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Material Science: Potential application as a monomer or functionalizing agent in the development of specialty polymers and advanced materials.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial production of fine chemicals.

Basic Information

Product Name	tert-Butyl 4-Fluoroindoline-1-Carboxylate
CAS No.	1037075-45-8
Molecular Formula	C₁₃H₁₆FNO₂
Molecular Weight	237.27 g/mol
Synonyms	1-Boc-4-fluoroindoline; 4-Fluoroindoline-1-carboxylic acid tert-butyl ester; tert-Butyl 4-fluoro-2,3-dihydro-1H-indole-1-carboxylate; 1-N-Boc-4-fluoroindoline; 4-Fluoro-1-indolinecarboxylic acid, 1,1-dimethylethyl ester; Boc-4-fluoroindoline; 1037075-45-8
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Fluoroindoline-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to guarantee consistency and traceability for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.