Description

(6-Amino-3-Bromo-2-Fluorophenyl)Methanol CAS NO 1036756-04-3 is a high-purity, multifunctional aromatic building block featuring amino, bromo, fluoro, and hydroxymethyl substituents. This compound is critical for the synthesis of complex molecules, offering versatile sites for further functionalization and coupling reactions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and other small-molecule drug discovery programs.
• Agrochemical Synthesis: Serves as a versatile precursor for constructing novel herbicides, fungicides, and insecticides, leveraging the reactivity of its halogen and functional groups.
• Material Science Research: Used in the synthesis of specialty polymers, liquid crystals, and organic electronic materials due to its rigid, substituted benzene core.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig amination.
• Fluorinated Compound Library: An essential building block for medicinal chemistry libraries focused on fluorinated bioisosteres to modulate pharmacokinetic properties.
• Chemical Derivatization: The amino and alcohol groups allow for amide bond formation, esterification, and reductive amination to create diverse chemical scaffolds.

Basic Information

Product Name	(6-Amino-3-Bromo-2-Fluorophenyl)Methanol
CAS No.	1036756-04-3
Molecular Formula	C7H7BrFNO
Molecular Weight	220.04 g/mol
Synonyms	2-Fluoro-6-amino-3-bromobenzyl alcohol; (2-Fluoro-6-amino-3-bromophenyl)methanol; 3-Bromo-2-fluoro-6-(hydroxymethyl)aniline; 2-Amino-5-bromo-6-fluorobenzyl alcohol; 6-Amino-3-bromo-2-fluorobenzyl alcohol; 3-Bromo-2-fluoro-6-(hydroxymethyl)benzenamine
EINECS	Contact for details

Quality Control

Our (6-Amino-3-Bromo-2-Fluorophenyl)Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light). Keep container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.