Description

1,2,3,4-Tetrahydro-Isoquinoline-5-Carboxylic Acid Methyl Ester Hcl is a high-purity, versatile heterocyclic building block essential for advanced organic synthesis. This compound is valued for its role as a key intermediate in the development of complex pharmacologically active molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used as a scaffold for constructing novel compound libraries in high-throughput screening and lead optimization programs.
• Organic Synthesis Building Block: Serves as a versatile starting material for constructing complex isoquinoline-based heterocycles and alkaloid analogs.
• Agrochemical Development: Employed in the research and synthesis of novel crop protection agents and pesticides.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	1,2,3,4-Tetrahydro-Isoquinoline-5-Carboxylic Acid Methyl Ester Hcl
CAS No.	1035700-06-1
Molecular Formula	C12H15NO2·HCl
Molecular Weight	241.71 g/mol (Free base: 205.25 g/mol)
Synonyms	Methyl 1,2,3,4-tetrahydroisoquinoline-5-carboxylate hydrochloride; 5-Carbomethoxy-1,2,3,4-tetrahydroisoquinoline HCl; 1,2,3,4-Tetrahydro-5-isoquinolinecarboxylic acid methyl ester hydrochloride; THIQ-5-COOMe·HCl; 5-Methoxycarbonyl-1,2,3,4-tetrahydroisoquinoline hydrochloride; Methyl 5,6,7,8-tetrahydroisoquinoline-5-carboxylate hydrochloride; 1035700-06-1
EINECS	Contact for details

Quality Control

Our production of 1,2,3,4-Tetrahydro-Isoquinoline-5-Carboxylic Acid Methyl Ester Hcl adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We support our commitment to quality with comprehensive analytical documentation. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed to minimize exposure to atmospheric moisture and light to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.